Which of the following is a symptom of Lyme disease?

The distinctive bulls-eye lesion around the bite is indeed a hallmark symptom of Lyme disease. This characteristic rash, known as erythema migrans, typically appears at the site of a tick bite and is circular with a clearer center, resembling a target or "bull's-eye." It is significant not only because of its unique appearance but also because it helps in distinguishing Lyme disease from other tick-borne illnesses. Recognizing this rash can prompt early medical intervention, essential for effective treatment of the disease.

In contrast, while joint swelling is a common symptom associated with Lyme disease during its later stages, it may not be as definitive as the bulls-eye lesion. Coughing and nasal discharge are symptoms more commonly related to respiratory conditions and are not characteristic of Lyme disease. Therefore, understanding the specific symptoms that are directly linked to Lyme disease is crucial for appropriate diagnosis and treatment.